Role of Genes Mesothelin in Cancer Establishment

Role of Genes Mesothelin - The Researcher from Japan, latest have research the mechanism from gen mesothelin that get effect of malignant mesothelioma. This study published in doctoral journal of Human Pathology.

Mesothelioma is a rare cancer that occurs almost entirely caused by exposure to asbestos. Since there is no cure for this disease, life expectancy for most mesothelioma patients ranged between four and 18 months after diagnosis of mesothelioma is known for sure. Although there is no cure to date, some patients who are diagnosed early mesothelioma can be given a combination of aggressive therapy, such as surgery, chemotherapy and radiation. Combination therapy, known as multimodality therapy, currently has the best chance to prolong the life of the patient.

The study's authors explain, "Gene methylation led to the development of malignant tumors in several tumor [malignant mesothelioma] are histologically divided into 3 subtypes, namely, epithelioid, sarcomatoid, and biphasic type, and it shows that mesothelin expression is restricted to epithelioid type and the epithelioid component of biphasic MM type (malignant mesothelioma). However, the mechanism of expression regulation has not been clarified. "
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